CRC 656 B07 - Mathematical Modelling of Atherosclerotic Plaque Formation Based on Data from Multiparametric Imaging

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration: 01/07/2013 - 30/06/2017 | 1st Funding period

Description

Most vascular pathologies arise from atherosclerosis. Atherogenesis is an inflammatory process mainly triggered by low-density lipoproteins entering the intimal layer of arteries. This phenomenon in turn is regionally related to a blood flow dependent change in endothelial shear stress. We aim at numerical modeling of atherogenesis based on multiparametric imaging data of vessel architecture, blood flow and vascular inflammation. Simulation-based characterisation of the dependence of plaque formation on critical parameters should finally support our understanding of plaque development.

Keywords: Mathematical Modelling; Atherosclerotic Plaque; Multiparametric Imaging