Phosphorescent Pt(II) complexes spatially arrayed in micellar polymeric nanoparticles providing dual readout for multimodal imaging

Proetto, M. T.; Sanning, J.; Peterlechner, M.; Thunemann, M.; Stegemann, L.; Sadegh, S.; Devor, A.; Gianneschi, N. C.; Strassert, C. A.

Abstract

In this paper we report phosphorescent Pt(ii) complexes as monomers which can be directly incorporated into growing polymers. Due to the amphiphilic nature of the polymers they can self-assemble into micellar nanoparticles{,} where the phosphorescent Pt(ii) complexes can arrange selectively in the core or shell of the nanoparticles. The complexes enable dual orthogonal imaging{,} made possible by the heavy metal{,} which enhances the contrast for these micelles in electron microscopy and facilitates spin–orbit coupling that turns on microsecond lifetime luminescence.