Design and development of 9,10-dihydrophenanthrene derivatives as inhibitors of human protein kinase CK2
Haidar S, Meyers A, Jose J
Abstract in digital collection (conference) | Peer reviewedAbstract
ProteinkinaseCK2isanemergingtargetforthetherapeuticinterventioninhumandiseases,particularlyincancer.Inhibitorsofthisenzymearecurrentlyinclinicaltrials,indicatingthedruggabilityofhumanCK2.Herewereportonthedesignofseveralderivativesof9,10-Dihydrophenanthrenewithdi-substitutedfunctionalgroups,usingamolecularmodelingapproach.TheinhibitoryactivityofthesynthesizedcompoundstowardsCK2wastestedusingacapillaryelectrophoresisin-vitroapproach.Furthermore,breastcancercells(MCF-7)weretreatedwiththedesignedcompoundsandcellviabilitywasdeterminedusingtheMTTassay.MolecularmodelingstudieswereperformedusingMOEsoftwaretounderstandthebindingaffinitiesofthedesignedcompounds.
Details about the publication
Status: Published
Release year: 2016
Language in which the publication is written: English
Conference: 2nd Electronic Conference on Medicinal Chemistry, Basel, undefined
Authors from the University of Münster
| Jose, Joachim | Professur für Pharmazeutische Chemie (Prof. Jose) Center of Interdisciplinary Sustainability Research (ZIN) |