Bioinspired Patterning with Extreme Wettability Contrast on TiO2 Nanotube Array Surface: A Versatile Platform for Biomedical Applications

Lai Y, Lin L , Pan F , Huang J, Song R , Huang Y, Lin C, Fuchs H, Chi LF

Research article (journal)

Abstract

Binary wettability patterned surfaces with extremely high wetting contrasts can be found in nature on living creatures. They offer a versatile platform for microfluidic management. In this work, a facile approach to fabricating erasable and rewritable surface patterns with extreme wettability contrasts (superhydrophilic/superhydrophobic) on a TiO2 nanotube array (TNA) surface through self-assembly and photocatalytic lithography is reported. The multifunctional micropatterned superhydrophobic TNA surface can act as a 2D scaffold for site-selective cell immobilization and reversible protein absorption. Most importantly, such a high-contrast wettability template can be used to construct various well-defined 3D functional patterns, such as calcium phosphate, silver nanoparticles, drugs, and biomolecules in a highly selective manner. The 3D functional patterns would be a versatile platform in a wide range of applications, especial for biomedical devices (e.g., high-throughput molecular sensing, targeted antibacterials, and drug delivery). In a proof-of-concept study, the surface-enhanced Raman scattering and antibacterial performance of the fabricated 3D AgNP@TNA pattern, and the targeted drug delivery for site-specific and high-sensitivity cancer cell assays was investigated.

Details zur Publikation

Pages: 9
Release year: 2013
Language in which the publication is written: English