A metal-mediated base pair with a [2+1] coordination environment

Richters T, Müller J

Research article (journal)

Abstract

A silver(I)-mediated base pair based on azole-derived ligands only was devised. The base pair comprises the monodentate imidazole nucleoside and a nucleoside carrying the new bidentate ligand 4-[(1H-1,2,4-triazol-1-yl)methyl]- 1H-1,2,3-triazole. The silver(I) ion is hence coordinated in a trigonal planar [2+1] environment. A representative DNA duplex comprising the new base pair is stabilized by 6 °C upon binding one equivalent of silver(I). CD spectroscopy was used to confirm that the duplex adopts the canonical B-type conformation. The base pair represents the first example of a metal-mediated base pair with a [2+1] coordination environment. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Details zur Publikation

Pages: 5
Release year: 2014
Language in which the publication is written: English
Link to the full text: http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84892930354