CRC 858 B09 - Influence of consecutive metal-mediated base pairs in DNA double helices on charge transfer through DNA and other cooperative effects in metal-modified DNA (SFB 858)

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration: 01/01/2010 - 31/12/2017 | 2nd Funding period

Description

The DNA molecule represents also the key compound within project B9. On the basis of artificial metal-mediated base pairs with known geometry, we intend to generate and characterize double helices with a structure analogous to that suggested for M-DNA. We will study the influence of the artificial base pairs on charge transfer through the DNA helix. Based on sequences originally investigated for non-modified DNA, we will subsequently replace the natural base pairs by artificial metal-mediated ones and analyze a potential correlation between the efficiency of the charge transfer and the number and position of the incorporated metal ions. Both hole transfer and excess electron transfer will be studied.

Keywords: DNA; metal-mediated base pairs; double helices; charge transfer; electron transfer; hole transfer