pH and Ion Transport in Pancreatic Cancer (pHioniC)

Basic data for this project

Type of project: EU-project hosted at University of Münster
Duration: 01/11/2018 - 30/06/2023

Description

The molecular mechanisms that give rise to pancreatic cancer remain elusive with hardly any targeted therapies available today. The working hypothesis of the EU-funded pHioniC project is that the pancreas has a unique acidic environment that may facilitate pancreatic cancer initiation and progression. The alkaline pancreatic juice secreted to neutralise the acidic chyme that arrives from the stomach induces temporal changes in pH levels which may drive oncogenic mutations. Researchers will map the pancreatic pH landscape and investigate the mechanism by which it can influence disease progression. Moreover, they will explore potential pH interventions to alter the disease course.

Keywords: pancreatic cancer; physiology; mutation