CRC 1450 B02 - Quantitative MRI of organ-specific vascular permeability and immune cell dynamics by combination with mass spectrometric imaging

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration: 01/01/2021 - 31/12/2024 | 1st Funding period

Description

The aim of this project is to develop combined in vivo MRI and ex vivo mass spectrometry imaging (MSI) methods including both, laser ablation-inductively coupled plasma-mass spectrometry imaging (LA-ICP-MSI) and matrix-assisted laser desorption/ionisation mass spectrometry imaging (MALDI-MSI). MSI shall be used to develop fully quantitative MRI methods as part of our comprehensive multiscale imaging strategy to analyse immune responses in disease models and patients in vivo. The overarching question is how quantitative MR parameters depend on elemental and molecular patterns in tissues, and how this dependence evolves during inflammatory responses.

Keywords: MRI; mass spectrometry; Radiology; Nuclear Medicine; Radiotherapy; Radiobiology