Modulating the G-Quadruplex and Duplex DNA Binding by Controlling the Charge of Fluorescent Molecules

Gil-Martínez, Ariadna; López-Molina, Sònia; Galiana-Roselló, Cristina; Lázaro-Gómez, Andrea; Schlüter, Friederike; Rizzo, Fabio; González-García, Jorge

Forschungsartikel (Zeitschrift)

Zusammenfassung

Two fluorescent and non-toxic spirobifluorene molecules being either positive (Spiro-NMe3) or negative (Spiro-SO3) charged have been investigated as DNA binders. Both molecules show a moderate binding to G-quadruplex and duplex DNA structures whereas the interaction is governed by the overall charge of the ligands.

Details zur Publikation

Veröffentlichungsjahr: 2023
Sprache, in der die Publikation verfasst ist: Englisch
Link zum Volltext: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202203094