European Vigilance Network for the Management of Antiviral Drug Resistance

Grunddaten zu diesem Projekt

Art des Projektes: EU-Projekt koordiniert außerhalb der Universität Münster
Laufzeit: 01.05.2004 - 31.10.2008

Beschreibung

The overall objective of the viRgil Network of Excellence is to set up the first-ever European Vigilance Network capable of addressing current and emerging antiviral drugs resistance developments. Focusing first on three major diseases (influenza and viral hepatitis B and C), our strategy is to build a sustainable, patient-oriented 'virtual institute' by integrating the currently fragmented European capacities into interacting platforms that together will allow the containment of the problem of viral drug resistance. Being approach- rather than virus- based, the integration process will be flexible enough to embrace in the future drug resistance problems related to other human viruses. Indeed, the proposed complementary platforms will focus each on a topic contributing towards broad objectives: the setting-up of the viRgil clinical platforms (surveillance and virology) will allow a global approach for monitoring, testing and ultimately improving the management of antiviral drug resistance in treated patients, leading to outstanding practices and standards in Europe. Attention will be paid to specific patient communities (children, women). These activities will be strengthened by knowledge generated from the in vitro and in vivo models platform, which will elucidate the mechanisms of the the development of resistance, and from the host determinants platform aiming at understanding patient-related (immune/genetic) factors conditioning viral drug resistance. Platforms dedicated to drugs and pharmacological aspects as well as innovation and technology will enable to anticipate viral resistance against promising drugs closed to clinical application and to overcome future resistance problems by proposing more rational approaches for drug development to the private sector and effective tools for testing resistance to the clinicians. Lastly, viRgil objectives and the benefit for the community will be constantly evaluated by the societal impact platforrm.

Stichwörter: Antiviral Drug Resistance