Ligand-Controlled Highly Regioselective and Asymmetric Hydrogenation of Quinoxalines Catalyzed by Ruthenium N-Heterocyclic Carbene Complexes.
Urban S, Ortega N, Glorius F
Research article (journal)Abstract
Proper choice of the N-heterocyclic carbene (NHC) ligand in Ru NHC complexes allows the completely regioselective ligand-controlled hydrogenation of either the heterocyclic or the carbocyclic ring of a substituted quinoxaline in quantitative yields. Chiral NHC ligands allow the challenging asymmetric hydrogenation of the carbocyclic ring of quinoxalines, yielding enantioenriched 5,6,7,8-tetrahydroquinoxalines with an enantiomeric ratio of up to 94:6.
Details about the publication
Journal: Angewandte Chemie International Edition (Angew. Chem. Int. Ed.)
Volume: 50
Issue: 16
Page range: 3803-3806
Status: Published
Release year: 2011 (25/03/2011)
Language in which the publication is written: Uncoded languages
Authors from the University of Münster
| Glorius, Frank | Professur für Organische Chemie (Prof. Glorius) |
| Ortega Hernandez, Nuria | Organic Chemistry Institute |
| Urban, Slawomir | Sonderforschungsbereich 858 - "Synergetische Effekte in der Chemie - Von der Additivität zur Kooperativität" |