Rh(III)-Catalyzed Directed C-H Olefination Using an Oxidizing Directing Group: Mild, Efficient, and Versatile
Rakshit S, Grohmann C, Besset T, Glorius F
Research article (journal)Abstract
An efficient Rh(III)-catalyzed oxidative olefination by directed C-H bond activation of N-methoxybenzamides is reported. In this mild, practical, selective, and high-yielding process, the N-O bond acts as an internal oxidant. In addition, simply changing the substituent of the directing/oxidizing group results in the selective formation of valuable tetrahydroisoquinolinone products.
Details about the publication
Journal: Journal of the American Chemical Society (J. Am. Chem. Soc.)
Volume: 133
Issue: 8
Page range: 2350-2353
Status: Published
Release year: 2011 (02/03/2011)
Language in which the publication is written: English
DOI: 10.1021/ja109676d
Keywords: catalyzed direct arylation n bond formation pd(ii)-catalyzed olefination activation reactions benzoic-acids cleavage alkynes anilides oxidant arenes
Authors from the University of Münster
| Besset, Tatiana | Sonderforschungsbereich 858 - "Synergetische Effekte in der Chemie - Von der Additivität zur Kooperativität" |
| Glorius, Frank | Professur für Organische Chemie (Prof. Glorius) |
| Grohmann, Christoph | Organic Chemistry Institute |
| Rakshit, Souvik | Organic Chemistry Institute |