Palladium-catalyzed C-allylation of benzoins and an NHC-catalyzed three component coupling derived thereof: Compatibility of NHC- and Pd-catalysts
Lebeuf R, Hirano K, Glorius F
Research article (journal)Abstract
A large range of benzoins was successfully applied as C-nucleophiles in the palladium-catalyzed allylic alkylation with several allyl acetates, resulting in functionalized tertiary homoallylic alcohols. A number of unsymmetrical benzoins can be coupled with high levels of regio- and chemoselectivity. Finally, the challenging compatibility of free N-heterocyclic carbenes with a palladium catalyst has been utilized in a number of metal- and organocatalyzed three-component coupling reactions.
Details about the publication
Journal: Organic letters (Org Lett)
Volume: 10
Issue: 19
Page range: 4243-4246
Status: Published
Release year: 2008 (02/10/2008)
Language in which the publication is written: English
DOI: 10.1021/ol801644f
Keywords: asymmetric allylic alkylation transition-metal catalysis gamma-butyrolactones alpha; beta-unsaturated aldehydes nucleophilic carbenes conjugate umpolung organocatalysis route acid dihydropyrans
Authors from the University of Münster
| Glorius, Frank | Professur für Organische Chemie (Prof. Glorius) |