N-Heterocyclic Carbene-Catalyzed Cascade Reaction Involving the Hydroacylation of Unactivated Alkynes
Biju AT, Wurz NE, Glorius F
Research article (journal)Abstract
The N-heterocyclic carbene (NHC)-catalyzed hydroacylation of unactivated alkynes to provide alpha,beta-unsaturated ketones is reported. In addition, a rare case of an efficient and selective dually NHC-catalyzed cascade reaction involving the hydroacylation of alkynes and a subsequent intermolecular Stetter reaction allows the formation of chromanones containing a 1,4-diketone moiety.
Details about the publication
Journal: Journal of the American Chemical Society (J. Am. Chem. Soc.)
Volume: 132
Issue: 17
Page range: 5970null
Status: Published
Release year: 2010 (05/05/2010)
Language in which the publication is written: English
DOI: 10.1021/ja102130s
Keywords: intramolecular stetter reaction activated double-bonds gamma-butyrolactones alpha; beta-unsaturated aldehydes benzoin condensation conjugate umpolung direct annulations efficient enals hydroamination
Authors from the University of Münster
| Akkattu, Biju | Organic Chemistry Institute |
| Glorius, Frank | Professur für Organische Chemie (Prof. Glorius) |