Intermolecular N-Heterocyclic Carbene Catalyzed Hydroacylation of Arynes
Biju AT, Glorius F
Research article (journal)Abstract
The conceptually new N-heterocyclic carbene catalyzed formal insertion of arynes into the Cformyl H bond of aldehydes demonstrates the compatibility of nucleophilic NHCs with electrophilic arynes. This NHC-catalyzed hydroacylation of arynes allows the conversion of aliphatic, α,β-unsaturated, and aromatic aldehydes into aryl ketones; 27 examples and a preliminary mechanistic investigation are provided.
Details about the publication
Journal: Angewandte Chemie International Edition (Angew. Chem. Int. Ed.)
Volume: 49
Issue: 50
Page range: 9761-9764
Status: Published
Release year: 2010 (31/12/2010)
Language in which the publication is written: English
Keywords: arynes benzophenones hydroacylation N-heterocyclic carbenes organocatalysis cope-type hydroamination straightforward synthesis aromatic-aldehydes regioselective synthesis gamma-butyrolactones general-synthesis coupling reaction terminal alkynes easy access benzyne
Authors from the University of Münster
| Akkattu, Biju | Organic Chemistry Institute |
| Glorius, Frank | Professur für Organische Chemie (Prof. Glorius) |