Copper-Catalyzed Synthesis of 2-Unsubstituted, N-Substituted Benzimidazoles
Hirano K, Biju AT, Glorius F
Research article (journal)Abstract
An efficient copper-catalyzed intramolecular arylation of formamidines forming 2-unsubstituted benzimidazoles in excellent yields is reported. Sixteen examples bearing sterically demanding substituents on nitrogen like Mes, 2,6-diisopropylphenyl, or 2-tert-butylphenyl and tolerating various functional groups demonstrate the utility of this method.
Details about the publication
Journal: Journal of Organic Chemistry (J. Org. Chem.)
Volume: 74
Issue: 24
Page range: 9570-9572
Status: Published
Release year: 2009 (18/12/2009)
Language in which the publication is written: English
DOI: 10.1021/jo902160y
Keywords: heterocyclic carbene ligands cross-coupling reactions gamma-butyrolactones conjugate umpolung azolium salts c-n 1,3-dimethylbenzimidazolium iodide alpha; beta-unsaturated aldehydes restricted flexibility palladium complexes
Authors from the University of Münster
| Akkattu, Biju | Organic Chemistry Institute |
| Glorius, Frank | Professur für Organische Chemie (Prof. Glorius) |