Controlled Iterative Cross-Coupling: On the Way to the Automation of Organic Synthesis
Wang CY, Glorius F
Research article (journal)Abstract
New strategies for the modulation of the reactivity of difunctional building blocks are discussed, allowing the palladium-catalyzed controlled iterative cross-coupling and, thus, the efficient formation of complex molecules of defined size and structure (see scheme). As in peptide synthesis, this development will enable the automation of these reactions. MPG=protected metal, Mact=metal.
Details about the publication
Journal: Angewandte Chemie International Edition (Angew. Chem. Int. Ed.)
Volume: 48
Issue: 29
Page range: 5240-5244
Status: Published
Release year: 2009 (31/12/2009)
Language in which the publication is written: English
Keywords: automation catalysis cross-coupling iterative synthesis palladium repetitive 2-step method hydroxyphenylboronic acids conjugated oligomers oligoarene synthesis direct arylation alkyl-halides strategy functionalization reagents homologation
Authors from the University of Münster
| Glorius, Frank | Professur für Organische Chemie (Prof. Glorius) |