Asymmetric Cross-Coupling of Non-Activated Secondary Alkyl Halides
Glorius F
Research article (journal)Abstract
First reports on asymmetric cross-coupling reactions of racemic activated and non-activated secondary alkyl halides highlight the particular suitability of nickel catalysts for these reactions. Impressively high enantioselectivities were observed for Negishi, Hiyama, and Suzuki-Miyaura cross-coupling reactions (see scheme). The results can be expected to change retrosynthetic thinking.
Details about the publication
Journal: Angewandte Chemie International Edition (Angew. Chem. Int. Ed.)
Volume: 47
Issue: 44
Page range: 8347-8349
Status: Published
Release year: 2008 (31/12/2008)
Language in which the publication is written: English
Keywords: asymmetric catalysis cross-coupling Negishi coupling nickel Suzuki-Miyaura coupling aryl grignard-reagents room-temperature negishi reactions suzuki reactions beta-hydrogens chlorides bromides catalysts iodides complex
Authors from the University of Münster
| Glorius, Frank | Professur für Organische Chemie (Prof. Glorius) |