A domino copper-catalyzed C-N and C-O cross-coupling for the conversion of primary Amides into oxazoles

Schuh K, Glorius F

Abstract

A variety of oxazoles can efficiently be prepared, in a single step and in good yield, from primary amides and 1,2-dihaloalkenes using copper-catalysis. This new method allows the regioselective formation of a range of substituted oxazoles. The required 1,2-dihaloalkenes can prepared by simple treatment of alkynes with elemental bromine or iodine.