Palladium-Catalyzed Intramolecular Direct Arylation of Benzoic Acids by Tandem Decarboxylation/C-H Activation
Wang C, Piel I, Glorius F
Research article (journal)Abstract
A novel protocol for the palladium-catalyzed intramolecular direct arylation of benzoic acids is reported, which combines decarboxylation and C-H activation into one efficient process. With the optimized catalyst system of palladium trifluoroacetate, silver carbonate, and the proper solvent mixture (5% DMSO/dioxane), dibenzofuran derivatives are formed in excellent yield and selectivity.
Details about the publication
Journal: Journal of the American Chemical Society (J. Am. Chem. Soc.)
Volume: 131
Issue: 12
Page range: 4194-4195
Status: Published
Release year: 2009
DOI: 10.1021/ja8100598
Keywords: PROTON-ABSTRACTION MECHANISM; HETEROCYCLIC CARBENE LIGANDS; CROSS-COUPLING REACTION; ARYL BOND FORMATION; CARBOXYLIC-ACIDS; BIARYL SYNTHESIS; RESTRICTED FLEXIBILITY; AROMATIC CARBOXYLATES; UNACTIVATED ARENES; FUNCTIONALIZATION
Authors from the University of Münster
| Glorius, Frank | Professur für Organische Chemie (Prof. Glorius) |