Palladium-Catalyzed Amidation of Unactivated C(sp(3))-H Bonds: from Anilines to Indolines
Neumann JJ, Rakshit S, Dröge T, Glorius F
Research article (journal)Abstract
Unreactive CH to attractive CN: A palladium-catalyzed intramolecular direct amidation of unactivated C(sp3)H bonds combines CH activation and CN bond formation into one efficient process. Under the optimized conditions, an extraordinary tolerance of functional groups was observed, and numerous indoline derivatives were formed (see scheme).
Details about the publication
Journal: Angewandte Chemie International Edition (Angew. Chem. Int. Ed.)
Volume: 48
Issue: 37
Page range: 6892-6895
Status: Published
Release year: 2009 (31/12/2009)
Language in which the publication is written: English
Keywords: C-H activation heterocycles homogeneous catalysis indolines palladium c-h bonds heterocyclic carbene ligands direct arylation regiospecific functionalization restricted flexibility substituted indolines mild conditions methyl-groups aryl halides alkyl-groups
Authors from the University of Münster
| Dröge, Thomas | Organic Chemistry Institute |
| Glorius, Frank | Professur für Organische Chemie (Prof. Glorius) |
| Rakshit, Souvik | Organic Chemistry Institute |