Towards mild metal-catalyzed C-H bond activation.

Wencel-Delord J, Dröge T, Liu F, Glorius F

Forschungsartikel (Zeitschrift)

Zusammenfassung

Functionalizing traditionally inert carbon-hydrogen bonds represents a powerful transformation in organic synthesis, providing new entries to valuable structural motifs and improving the overall synthetic efficiency. C-H bond activation, however, often necessitates harsh reaction conditions that result in functional group incompatibilities and limited substrate scope. An understanding of the reaction mechanism and rational design of experimental conditions have led to significant improvement in both selectivity and applicability. This critical review summarizes and discusses endeavours towards the development of mild C-H activation methods and wishes to trigger more research towards this goal. In addition, we examine select examples in complex natural product synthesis to demonstrate the synthetic utility of mild C-H functionalization (84 references).

Details zur Publikation

FachzeitschriftChemical Society Reviews
Jahrgang / Bandnr. / Volume40
Ausgabe / Heftnr. / Issue9
Seitenbereich4740-4761
StatusVeröffentlicht
Veröffentlichungsjahr2011 (15.09.2011)
Sprache, in der die Publikation verfasst istEinzelne andere Sprachen
DOI10.1039/c1cs15083a

Autor*innen der Universität Münster

Glorius, Frank
Professur für Organische Chemie (Prof. Glorius)