N-Heterocyclic Carbene-Catalyzed Cross-Coupling of Aromatic Aldehydes with Activated Alkyl Halides

Padmanaban M, Biju AT, Glorius F

Forschungsartikel (Zeitschrift)

Zusammenfassung

N-Heterocyclic carbene-catalyzed umpolung of aldehydes followed by their interception with diarylbromomethanes has been reported. This conceptually novel transition-metal-free cross-coupling of aldehydes with alkyl halides works well at low catalyst loadings and under mild reaction conditions leading to the formation of diaryl acetophenone derivatives in good yields. In addition, a-halo ketones and esters can also be used, as aldehyde reaction partners.

Details zur Publikation

FachzeitschriftOrganic letters (Org Lett)
Jahrgang / Bandnr. / Volume13
Ausgabe / Heftnr. / Issue1
Seitenbereich98-101
StatusVeröffentlicht
Veröffentlichungsjahr2011 (07.01.2011)
Sprache, in der die Publikation verfasst istEnglisch
DOI10.1021/ol102626p
Stichwörterintramolecular stetter reaction gamma-butyrolactones alpha; beta-unsaturated aldehydes benzoin condensation direct annulations nhc ketones umpolung hydroacylation ligands

Autor*innen der Universität Münster

Akkattu, Biju
Organisch-Chemisches Institut
Glorius, Frank
Professur für Organische Chemie (Prof. Glorius)